![]() ![]() We utilise high-resolution analytical techniques –including multi-parameter flow cytometry, two-photon microscopy, immunofluorescence histology, gene array and single-cell mutation analysis – to create an integrated view of B cell proliferation, survival, differentiation and migration. Our lab employs cutting-edge genetic engineering approaches to observe and understand the complex and dynamic events that control B cells. We aim to understand not only how highly protective antibodies are formulated in germinal centres but also how the production of disease-causing autoantibodies or allergic antibodies can result instead. ![]() These changes improve antibody effectiveness and are crucial for immune protection and effective vaccination. Within germinal centres, B cells undergo rapid and dramatic changes to their antibody genes. A major research focus of ours is the ‘germinal centre’, a specialised physiological structure that forms within lymphoid tissues during an immune response. Our lab aims to understand how the development, activation and responses of B cells are controlled, and how this impacts antibody production in both health and disease. While the presence of antibodies provides long-term immunity, those that inadvertently attack the body’s own tissues can give rise to autoimmune diseases, as well as asthma and some allergies. B lymphocytes – or B cells – are the components of the immune system responsible for making antibodies: soluble proteins that seek out and eliminate foreign entities in the body, like viruses.
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